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Monkeypox cases in Pakistan
Author: Dr. Ahmed Farhan, 1 year ago

Two cases of monkeypox have been reported in Pakistan. It manifests as: A rash similar to smallpox Fever, and Lymphadenopathy The diagnosis is made via PCR testing of fluid taken fro...


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Adcetris (Brentuximab Vedotin)
Author: Dr. Ahmed Farhan, 1 year ago

Adcetris is the brand name of Brentuximab Vedotin. This drug is unique as it has two different components:  Brentuximab and Vedotin Brentuximab is a monoclonal antibody that carries...


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Sparsentan
Author: owner, 1 year ago

Sparsentan is a newly approved drug by the FDA for the treatment of high-risk patients with IgA Nephropathy. It has a unique mechanism of action as it blocks two receptors simultaneously: Endoth...


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MAC (Mycobacterium Avium Complex)
Author: Dr. Ahmed Farhan, 1 year ago

How can we diagnose MAC infection?


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NOACs use associated with lung fibrosis
Author: Dr. Ahmed Farhan, 1 year ago

Factor Xa inhibitors (Rivaroxaban and Apixaban) use has been linked with lung fibrosis. This has been described as "association " rather than "causality". Patients already on...


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Neurology Examination
Author: Dr. Ahmed Farhan, 1 year ago

What is the most likely diagnosis if a young person has: 1. Spastic paraparesis ( hypertonia, hyperreflexia, and weakness), 2. impaired sensations with a sensory level of T2, 3. RAPD (relevan...


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Efgartigimod Alfa for generalized Myasthenia Gravis
Author: Dr. Ahmed Farhan, 1 year ago

Efgartigimod Alfa is a monoclonal antibody that is used in the treatment of generalized myasthenia gravis. It binds to the Fc receptors of human IgG-1 in patients who are Ach-R (acetylcholine receptor...


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Olpasiran for Lipoprotein a reduction
Author: Dr. Ahmed Farhan, 1 year ago

Olpasiran is a drug that is a "small interfering RNA". It inhibits lipoprotein synthase resulting in LDL-c lowering effect.


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Acute Myeloid Leukemia
Author: Dr. Ahmed Farhan, 1 year ago

The treatment of acute myeloid leukaemia (AML): 1. Anthracycline (Daunorubicin or Idarubicin) + 2. Cytarabine +/ - Gemtuzumab Ozogamicin Patients with secondary AML should recieve a liposomal...


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Dengue Fever
Author: Dr. Ahmed Farhan, 1 year ago

How often do you give corticosteroids in patients with dengue fever?


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Hand-Schüller-Christian disease
Author: Dr. Ahmed Farhan, 1 year ago

Hand-Schüller-Christian disease is a triad of: Diabetes Insipidus, Exophthalmos, and Lytic bone lesions It is one of the spectra of diseases called Langerhans Granulomatosis or Eo...


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Polycythemia
Author: Dr. Ahmed Farhan, 2 years ago

How can we differentiate between primary and secondary polycythemia?


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Male Hypogonadism
Author: Dr. Ahmed Farhan, 2 years ago

Hypogonadism is the combined deficiency of: 1. Gonadal androgens like testosterone, and 2. Deficient production of sperms and ova    


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Renal Tubular Disorders
Author: owner, 2 years ago

How do you differentiate between the different types of RTA (Renal Tubular Disorders)?


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Aortic Regurgitation
Author: owner, 2 years ago

What are the clinical signs of Aortic Regurgitation? Apex beat: Heart sounds: Murmur: Other features:


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Aortic stenosis
Author: owner, 2 years ago

What are the clinical signs of Aortic Stenosis? Apex beat: Heart sounds: Murmur: Other features:


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Hypogonadism
Author: owner, 2 years ago

What are the differences between Turner's syndrome and Klinefelter syndrome?


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Bartter syndrome Vs Liddle syndrome
Author: owner, 2 years ago

How can we differentiate between Bartter syndrome and Liddle syndrome?


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Infective endocarditis
Author: owner, 2 years ago

What are Roth's spots?


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Rare diseases
Author: owner, 2 years ago

What is Rosai Dorfman Disease?


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